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In a small percentage of patients, these treatment responses can last for years.ĭrugs called immune checkpoint inhibitors, for instance, are already in broad use to treat people with many types of cancer, including melanoma, lung, kidney, bladder, and lymphoma.īut another form of immunotherapy, called CAR T-cell therapy, has also generated substantial excitement among researchers and oncologists. That’s because immune system–boosting drugs have shown the ability to shrink, and even eradicate, tumors in some people with advanced cancer. Dozens of targeted therapies are now standard treatments for many cancers.Īnd over the past decade, immunotherapy-therapies that enlist and strengthen the power of a patient's immune system to attack tumors-has rapidly become what many call the 'fifth pillar' of cancer treatment.

The 2000s marked the emergence of targeted therapies like imatinib (Gleevec) and trastuzumab (Herceptin)-drugs that find and kill cancer cells by homing in on specific molecular changes seen primarily in those cells. These continue to be critical mainstays of treatment, but new categories of treatment have recently helped transform the treatment picture for people with cancer. 2016 13, 370–383.įor decades, the foundations of cancer treatment have been surgery, chemotherapy, and radiation therapy. “Driving CAR T cells forward.” Nat Rev Clin Oncol.

#Tcel annual meeting 2017 how to#

Still figuring it out how to use it, since it can be applied to the machine learning to sort out some unwanted nucleus morphologies.Credit: Brentjens R, et al.

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Plus there are the webboards that are very interactive and helpful for finding the prototype pipeline to asking for help or fix your pipeline to run the analysis.

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This is also the free tool that you can write up your own pipeline and analyze the array of images. There are so many sources that I think it is very useful to read and do the self-study. I use this fluorescence microscopy quite often lately. Unified Data Resource for 3-Dimensional Electron Microscopyģ2.Cellosaurus - a knowledge resource on cell linesĤ3.Aspergillus Secondary Metabolites Database (A2MDB) 3-Dimensional Electron Microscopy (EMDatabank) To check the journal of interest fall into which quartileĢ7.

Online tool to check the lineage of cell linesĢ5.Traditional Chinese Medicine Database in Taiwan It also indicates the type of tumors where the mutations have been found as well as the number of cases.ġ8.OncoKB: A Precision Oncology Knowledge BaseĪn Online Catalog of Human Genes and Genetic Disorders The significant relies on the Q-value (more approaching to zero means very highly associated). This database provides the information about the frequently occur mutations of genes in cancer. Tool for retrieving the genome data on the cancers The Catalogue Of Somatic Mutations In Cancer - it is good for knowing the information on mutations of interested gene in all available types of cancer.

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It also has R-package which you can download and put the command to retrieve the data from the database. This website is extremely good for finding the mutations related to cancer. It is good to check whether the cell lines you are currently working with is authentic. Genomics of Drug Sensitivity in Cancer (GDSC)ġ0.Cancer Therapeutics Response Portal (CTRP)ġ1.The Library of Integrated Network-Based Cellular Signatures (LINCS)ġ2.IGRhCellID: integrated genomic resources of human cell lines for identification I have been working with genotoxic compounds and I need to find the information on the solubility of each compound and making the right preparation to treat the cells.ĩ. To tell us about which protein is up- or down-regulated during carcinogenesis.

I used this one to help me analyze the freely available microarray data that deposited on GEO dataset (NCBI). This is the website used for the gene profiles mapping. I really like the layout of this website. This one includes the expression profiles of all available species that deposit on the public database.